Before Alexander the Great's rise to prominence, the Macedonians had engaged in various conflicts and struggles, particularly during the reign of his father, King Philip II, who unified Macedonia and expanded its influence. Philip II ruled from 359 BC to 336 BC and fought numerous battles to consolidate power in the region, including conflicts with neighboring tribes and city-states such as Athens, Thebes, and various Greek city-states.
The Macedonian military campaigns leading up to Alexander's reign, especially under Philip II, can be traced back several years, as Philip's reign lasted about 23 years. By the time Alexander ascended the throne in 336 BC after the assassination of Philip, Macedonia had been involved in warfare and political maneuvers for over two decades.
Alexander's famous speech, where he inspired his troops before his campaigns, likely occurred shortly after he became king in 336 BC, culminating in his campaign against the Persian Empire starting in 334 BC. So, in total, if considering Philip II's reign and the military actions prior to and leading up to Alexander taking command, the Macedonians had been involved in military efforts for roughly two to three decades before Alexander's notable speeches and campaigns began.