The correct distinction between a nuclear reaction and a chemical reaction is that in a nuclear reaction, the particles in the nucleus are changed, and one element can be transformed into another. In a chemical reaction, electrons are exchanged between atoms or molecules, leading to the formation of different substances without altering the nuclei of the atoms involved.
Thus, the best response from the provided options is:
In a nuclear reaction, the particles in the nucleus are changed, and one element is transformed into another. In a chemical reaction, electrons are exchanged from one or more substances to produce a different substance.