The best response to explain the effect of South Carolina’s physical geography and climate on its role in mercantilism is: South Carolina’s physical geography and climate produced cash crops such as indigo, rice, and tobacco to trade as raw materials.
This response accurately reflects how the fertile soil and warm climate of South Carolina were conducive to the cultivation of lucrative cash crops, which were significant in the context of mercantilism. These crops were in high demand and played a crucial role in the colonial economy, allowing South Carolina to trade effectively with Great Britain and other markets.