The Indian Removal Act of 1830 primarily went against the Worcester v. Georgia ruling by ignoring the fact that Native Americans were sovereign nations and not technically part of the United States. In Worcester v. Georgia (1832), the Supreme Court ruled that the state of Georgia laws had no authority over the Cherokee Nation and that the federal government had a duty to protect the sovereignty of Native American nations.
The Indian Removal Act, however, authorized the forced removal of Native American tribes from their ancestral homelands, which directly contradicted the court's acknowledgment of their sovereignty and rights. Although the ruling was favorable to the Cherokee, the federal government, under President Andrew Jackson, chose to side with state interests rather than uphold the Court's decision, leading to the forced relocation known as the Trail of Tears.