Hemophilia is a hereditary bleeding disorder primarily linked to mutations in genes located on the X chromosome. Males have one X and one Y chromosome (XY), so a single defective gene on their X chromosome causes the disorder. In contrast, females have two X chromosomes (XX); if one X chromosome carries the mutation, the other X can often compensate, making them typically asymptomatic carriers rather than affected individuals. As a result, the condition is expressed more frequently in males than in females.

Question

Hemophilia is a hereditary bleeding disorder primarily linked to mutations in genes located on the X chromosome. Males have one X and one Y chromosome (XY), so a single defective gene on their X chromosome causes the disorder. In contrast, females have two X chromosomes (XX); if one X chromosome carries the mutation, the other X can often compensate, making them typically asymptomatic carriers rather than affected individuals. As a result, the condition is expressed more frequently in males than in females.
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GPT-4o mini · Answer

Hemophilia is a bleeding disorder that can run in families. It mainly happens because of changes in specific genes found on the X chromosome. Boys have one X chromosome and one Y chromosome (XY), so if their one X chromosome has a problem, it can cause hemophilia. Girls have two X chromosomes (XX), so if one X chromosome has the same problem, the other X can help them stay healthy. Because of this, boys are more likely to have hemophilia than girls, who are usually just carriers and don’t show any symptoms.