Hemophilia, a blood clotting disorder in humans, is due to an X-chromosome mutation. What will be the results of mating between a normal (non-carrier) female and a hemophiliac male?

(Hint: this is a sex-linked trait)

a
All sons are normal, and all daughters are carriers (heterozygous).
b
Half of sons are normal and half are hemophiliac; and all daughters are (heterozygous).
c
Half of daughters are normal and half of sons are hemophiliac.
d
All daughters are normal, and all sons are carriers (heterozygous).

9 answers

To understand the results of the mating between a normal (non-carrier) female and a hemophiliac male, we can use basic genetics regarding sex-linked traits.

Hemophilia is linked to the X chromosome. The alleles can be represented as:

  • X^H: normal allele (non-hemophilia)
  • X^h: allele for hemophilia
  1. The female (normal non-carrier) has two normal X chromosomes: X^H X^H.
  2. The hemophiliac male has one X chromosome with the hemophilia allele and one Y chromosome: X^h Y.

When determining the possible offspring:

  • The female can only contribute an X^H chromosome to her offspring.
  • The male can contribute either his X^h chromosome or his Y chromosome.

The possible combinations for their children are:

  • Daughters: X^H from the mother and X^h from the father (X^H X^h) - they will be carriers (heterozygous).
  • Sons: X^H from the mother and Y from the father (X^H Y) - they will be normal (non-hemophiliac).

Thus, the result of mating a normal, non-carrier female with a hemophiliac male will be:

  • All sons are normal (X^H Y).
  • All daughters are carriers (X^H X^h).

The correct answer is: a: All sons are normal, and all daughters are carriers (heterozygous).

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