To multiply two numbers in scientific notation, you multiply the coefficients and add the exponents of 10.
So we have: \[ 1.25 \times 10^5 \quad \text{and} \quad 2.2 \times 10^{-2} \]
First, multiply the coefficients: \[ 1.25 \times 2.2 = 2.75 \]
Next, add the exponents: \[ 5 + (-2) = 3 \]
Thus, when you multiply the two numbers, you get: \[ 2.75 \times 10^3 \]
The exponent of 10 after multiplication is \( \boxed{3} \).