To determine the type of mutation that has occurred leading to a genetic disorder based on a diagram, we would typically look for indications of how the DNA sequence is altered. Here’s how to differentiate between the options you’ve provided:
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Substitution: This mutation occurs when one base is replaced by another. It can lead to a change in a single amino acid in a protein.
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Deletion: This involves the removal of one or more bases in the DNA sequence, which can lead to a missing segment of protein.
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Frameshift: This mutation happens when bases are added or removed (not in multiples of three), shifting the reading frame of the genetic code. This often results in the production of an entirely different protein.
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Insertion: This involves adding one or more bases into the DNA sequence, which can also lead to a frameshift if not in multiples of three.
Without seeing the actual diagram, the distinction between a frameshift mutation and a substitution would be crucial. If the shift in amino acids or the entire reading frame is altered and results in a larger impact on the protein, then the mutation is likely a frameshift. If a single base is swapped out, then it would be a substitution.
If you can describe the diagram or give more context, I could provide a more accurate answer. However, based on typical interpretations, select frameshift if there is evidence of a significant change throughout the sequence.