To simplify the expression \( 6 \cdot 100 - 5 \cdot 4 \), we first calculate each part separately.
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Calculate \( 6 \cdot 100 \): \[ 6 \cdot 100 = 600 \]
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Calculate \( 5 \cdot 4 \): \[ 5 \cdot 4 = 20 \]
Now, we subtract the second result from the first: \[ 600 - 20 = 580 \]
Thus, the fully simplified result is: \[ \boxed{580} \]