Given the context of a diagnosis involving gene mutations along with sub-environmental factors, the most likely diagnosis for Trenton is Huntington's disease.
Huntington's disease is a genetic disorder caused by a mutation in the HTT gene, which provides instructions for making a protein called huntingtin. This condition follows an autosomal dominant inheritance pattern, meaning that only one copy of the mutated gene (inherited from either parent) is sufficient to cause the disease.
While sickle cell disease is also caused by a genetic mutation, it typically doesn't involve the same level of complexity with environmental factors in the same context. Color blindness generally involves a mutation but is more straightforward in its inheritance. Diabetes can have both genetic and environmental factors, but it is not primarily classified as a genetic mutation-related disease like Huntington's.
Therefore, Huntington's disease aligns best with the presented explanation.