To find the numerical equivalent of \( 5^{10} \times 5^{-6} \), we can use the properties of exponents. Specifically, we can add the exponents when multiplying like bases:
\[ 5^{10} \times 5^{-6} = 5^{10 - 6} = 5^4 \]
Now, we calculate \( 5^4 \):
\[ 5^4 = 5 \times 5 \times 5 \times 5 \]
Calculating step by step:
\[ 5 \times 5 = 25 \] \[ 25 \times 5 = 125 \] \[ 125 \times 5 = 625 \]
Therefore, the numerical equivalent of \( 5^{10} \times 5^{-6} \) is
\[ \boxed{625} \]