To find the missing number (let's call it \( x \)) in the equation
\[ x \times 0.1 = 22.1, \]
we can isolate \( x \) by dividing both sides of the equation by 0.1:
\[ x = \frac{22.1}{0.1}. \]
Calculating the right side:
\[ \frac{22.1}{0.1} = 221. \]
Therefore, the missing number is
\[ \boxed{221}. \]