625 factors into 5 * 5 * 5 * 5. You have to combine the above factors, so the difference will equal 120.
5 * 5 * 5 = 125
125 - 5 = 120, or even better 5 - 125 = -120
Therefore x^2-120xy-625y^2 = (x+5y)(x-125y)
Although this may not be the process you were seeking, I hope this helps. Thanks for asking.
Factorise by splitting the middle term:-
x^2-120xy-625y^2
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