Drag the terms on the left to the appropriate blanks on the right to complete the sentences. Terms can be used once, more than once, or not at all.

Question

Gene ______ (also called trans-acting regulatory proteins) are proteins that bind to DNA sequences and affect the _____ of one or more genes by either promoting or inhibiting the binding of_______ and_____ to______ . One mechanism by which transcription factors affect ______ binding is by directly or indirectly interacting with_____ and ______ , which then alter the _____ of the ____ . Specifically, ________ change chromatin structure by chemically modifying _______ in _________ , whereas _________ alter chromatin structure by changing the location of _______ or the composition of their ______ .

WORD BANK:
methylation
histone proteins
transcription factors
chromatin structures
chromatin remodeling proteins
chromatin modifying proteins
transcription
nucleosomes
genes
specific transcription factors
silencers
bases
promoters
RNA polymerase
enhancers

Answer 1

Gene transcription factors (also called trans-acting regulatory proteins) are proteins that bind to DNA sequences and affect the transcription of one or more genes by either promoting or inhibiting the binding of promoters and enhancers to silencers. One mechanism by which transcription factors affect RNA polymerase binding is by directly or indirectly interacting with chromatin modifying proteins and chromatin remodeling proteins, which then alter the structure of the chromatin. Specifically, chromatin modifying proteins change chromatin structure by chemically modifying bases in nucleosomes, whereas chromatin remodeling proteins alter chromatin structure by changing the location of specific transcription factors or the composition of their histone proteins.