Does this sentence make sense for destitute:

The poor children of the village were left in destitute.

?

or ..left destitute

2 answers

The poor children of the village were left destitute. look up the definition and you will see by the examples that this is the correct usage.
it issue is what part of speech is destiture? Noun or adjective?

in requires a noun, objective case; were
left requires an adjective, predicate adjective.