Question

Distribution of histamine
 Widely distributed in:- bacteria, plants, animals and
venoms and stinging fluids (stinging nettle, insect
stings, bee venom).
 Either stored or quickly inactivated (metabolism) by
histamine-N-methyltransferase (methylation) and
diamine oxidase (deamination) in the small intestine,
liver, kidney and skin.
5

Answer 1

 In humans, histamine is mainly found in mast cells and basophils in various tissues such as skin, lungs, and gastrointestinal tract.
 It is also present in certain foods such as aged cheese, fermented foods, and alcoholic beverages.
 Histamine plays a key role in allergic reactions, inflammation, and regulation of stomach acid production.
 Imbalance in histamine levels can lead to various health issues such as allergies, asthma, and digestive disorders.