To answer the question about what clue at the beginning could have helped predict the ending of "Puff and Pip Search for a Home," the most relevant clue is:
"Even though the two were very different, they depended on each other."
This statement implies a strong bond and collaboration between Puff and Pip, which is likely to impact their journey and the conclusion of the story. Their dependence on each other suggests that despite their differences, they would find a resolution together, leading to a more predictable and satisfying ending.