The situation describes Demetrius' budget for shirts. He can spend up to $50 on shirts that cost $16 each.
To represent this situation with an inequality, we need to express that the total spending, which is the cost of \( s \) shirts at $16 each (which is \( 16s \)), must be less than or equal to $50.
This can be written as:
\[ 16s \leq 50 \]
Therefore, the correct inequality that represents the situation is:
16s ≤ 50