To represent the situation where Demetrius can spend as much as $50 on shirts that cost $16 each, we need to set up an inequality based on the total cost of the shirts.
Let \( s \) represent the number of shirts. The total cost of \( s \) shirts, at $16 each, would be \( 16s \). We want this total cost to be less than or equal to $50.
So the inequality that represents this situation is:
\[ 16s \leq 50 \]
Therefore, the correct answer is:
16s ≤ 50