A)Convert the alkyl halide to a grignard and add formaldehyde, followed by H3O
Primary alcohols are synthesized from Grignard reagents and formaldehyde. Grignard reagents react with formaldehyde to form intermediate alkoxymagnesium halides. The alkoxymagnesium halides are hydrolyzed by mineral acids in water to produce primary alcohols:
Could someone answer this. Im stuck on it.
In general, the most elegant way to add one carbon with an OH on it to a primary alkyl halide:
A)Convert the alkyl halide to a grignard and add formaldehyde, followed by H3O
B)Convert the alkyl halide to a lithium dialkyl cuprate, and add formaldehyde followed by H3O
C)Convert the alkyl halide to an alcoho, oxidize the alcohol to an aldehyde and treat with methyl grignard followed by H3O.
D)Convert the alkyl halide to a grignard and add oxirane followed by H3O.
E)Convert the alkyl halde to a grignard and add ethyl formate.
1 answer