Consider the three different types of stem cells. Each one's ability to differentiate into new cells is slightly different. One type can differentiate into any cell, while another can only become specific cells. Select the answer that places the three types in the correct order, from widest range of differentiation to least able to differentiate (specific)

Question

A. totipotent, multipotent, pluripotent
B. pluripotent, totipotent, multipotent
C. pluripotent, lutipotent, totipotent
D. totipotent, pluripotent, multipotent

Answer 1

The correct order of stem cells from the widest range of differentiation to the least able to differentiate (specific) is:

D. totipotent, pluripotent, multipotent

• Totipotent stem cells can differentiate into any cell type, including both embryonic and extra-embryonic tissues (like the placenta).
• Pluripotent stem cells can differentiate into almost any cell type but cannot form an entire organism (they cannot develop into extra-embryonic tissues).
• Multipotent stem cells can only differentiate into a limited range of cell types, usually within a specific lineage.

Thus, totipotent has the widest range, followed by pluripotent, and finally multipotent.