Let's simplify the expression step by step.
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Simplify \( (16 - 12) \): \[ 16 - 12 = 4 \]
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Now calculate \( (16-12) \cdot 2 \): \[ 4 \cdot 2 = 8 \]
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Now simplify \( (8 + 22) \): \[ 8 + 22 = 30 \]
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Now calculate \( 5(8 + 22) \): \[ 5 \cdot 30 = 150 \]
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Now combine both parts of the expression: \[ 8 + 150 = 158 \]
Next, let's simplify the numerator \( 53 - (1 + 4) \cdot 2 \):
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Simplify \( (1 + 4) \): \[ 1 + 4 = 5 \]
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Now calculate \( (1 + 4) \cdot 2 \): \[ 5 \cdot 2 = 10 \]
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Now simplify \( 53 - 10 \): \[ 53 - 10 = 43 \]
So the simplified numerator is \( 43 \).
Thus, if we are to summarize the simplified expressions:
- The first expression results in \( 158 \) (though this was not explicitly asked)
- The simplified numerator \( 53 - (1 + 4) \cdot 2 = 43 \).
None of the options given in your question (4^2 + 60, 54, 76, 100) match the numerator or a derived value from our calculations. If reconsidering the calculations is needed, please specify the context further.