True.
The Fifth Amendment protects individuals from being compelled to provide testimonial evidence that could incriminate themselves. However, it's important to note that the U.S. Supreme Court has ruled that providing physical evidence (like handwriting samples) is generally not considered testimonial and, therefore, does not invoke Fifth Amendment protections.
That said, there can be nuances based on specific cases and circumstances, so the answer may depend on the context in which the handwriting sample is being requested. But the simple statement as presented can be deemed True for a general understanding of self-incrimination in the context of providing evidence. If your context or source has a specific legal interpretation or ruling, it may affect the assessment.