The most accurate response regarding the growth of Islam and Christianity in the Middle East between 300 and 1500 CE is:
"During this time, Islam became the dominant religion in the region. Christianity was less established in the Middle East during this time, but its influence was still felt during the Crusades."
Here's a brief explanation to support this statement:
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Christianity: By the early part of this timeframe (around 300 CE), Christianity was already growing and had become the dominant religion of the Eastern Roman Empire (Byzantine Empire). However, it was mainly centered in certain regions, particularly in the Eastern Mediterranean.
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Islam: With the rise of Islam in the 7th century (around 610 CE), it quickly expanded across the Middle East and beyond, often through conquests as well as trade. By the 8th century, Islam had become the dominant religion throughout much of the Middle East, replacing many areas where Christianity had been prevalent.
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Crusades: During the Crusades (from the late 11th century to the late 13th century), there were interactions and conflicts between Christians and Muslims, but by this time, Islam had well established itself as the leading religion in most parts of the Middle East.
Therefore, the statement accurately reflects the significance of Islam in the region by 1500 CE, especially considering the historical context of the events occurring in that period.