The correct comparison between a virus and a unicellular organism from the options provided is:
Unicellular organisms have a cell membrane made from a lipid bilayer; viruses have a protein coat.
This statement highlights a key structural difference: unicellular organisms are made up of cells that have a defined structure, including a cell membrane, while viruses are significantly simpler and are composed of genetic material surrounded by a protein coat, lacking cellular structures like membranes.
The other statements are inaccurate or misleading. For example, viruses do not need energy in the same way unicellular organisms do, as they rely on host cells for replication; and viruses do not reproduce through asexual reproduction, as they cannot replicate independently without a host cell. Additionally, both unicellular organisms and viruses can respond to stimuli in different ways.