The most accurate comparison between viruses and unicellular organisms from the responses provided is:
Unicellular organisms have a cell membrane made from a lipid bilayer; viruses have a protein coat.
Here’s a brief explanation for the other statements:
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Viruses need energy; unicellular organisms do not need energy. - This is incorrect. Both viruses and unicellular organisms require energy for various processes, but unicellular organisms can generate and use their energy through metabolic processes, whereas viruses do not have metabolic processes and rely on a host cell.
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Viruses reproduce through asexual reproduction; unicellular organisms need a host cell. - This is misleading. Viruses cannot reproduce independently and require a host cell to replicate; unicellular organisms can reproduce asexually (e.g., binary fission) without a host.
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Neither unicellular organisms nor viruses respond to stimuli. - This is not accurate. Unicellular organisms can respond to environmental stimuli, while viruses do not exhibit any form of response as they are not considered living organisms.
In summary, the fourth response regarding the structural differences of viruses and unicellular organisms is the best point of comparison.