The correct comparison between a virus and a unicellular organism is:
Unicellular organisms have a cell membrane made from a lipid bilayer; viruses have a protein coat.
This statement accurately describes a fundamental structural difference between the two entities. Unicellular organisms, like bacteria, have a cell membrane that regulates the movement of substances, while viruses have a protein coat (capsid) that protects their genetic material.
The other statements contain inaccuracies regarding reproduction and energy requirements. Viruses do not reproduce independently and require a host cell for replication, while unicellular organisms can reproduce asexually. Additionally, unicellular organisms do need energy to carry out metabolic processes.