The correct comparison between a virus and a unicellular organism from the provided options is:
Unicellular organisms have a cell membrane made from a lipid bilayer; viruses have a protein coat.
This statement accurately reflects the structural differences between unicellular organisms, which are living cells with cellular membranes, and viruses, which are non-living entities composed of genetic material encased in a protein coat.
The other statements contain inaccuracies, such as the reproduction methods and energy requirements of both entities. Viruses cannot reproduce on their own and require a host cell to replicate, while unicellular organisms can reproduce independently, often asexually. Additionally, both viruses and unicellular organisms require energy, but they obtain and use it in different ways.