Chromatography is a powerful analytical technique for separating complex mixtures into their components. Do you think it would be practical to use it on a large scale for preparative purposes? Consider the problems this would involve.

You have a product for which counterfeit material is being marketed. Suggest how in principle you could identify a sample as counterfeit or genuine.

1 answer

The answer to #1 depends upon how you define large scale. Chromatography has been used for prep purposes; as far as I know mg to g quantities can be prepared this way.

#2. In theory you could dissolve the material in some solvent and subject both to chromatography. See if the spots travel the same distance and both materials have the same spots.
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