To calculate \(6.25 \times 10^6 - 4.73 \times 10^6\), we first combine the coefficients since both terms have the same power of ten:
\[ (6.25 - 4.73) \times 10^6 \]
Calculating the coefficients:
\[ 6.25 - 4.73 = 1.52 \]
Now we can express the result in scientific notation:
\[ 1.52 \times 10^6 \]
Therefore, the final answer, expressed in scientific notation to two decimal places, is:
\[ \boxed{1.52 \times 10^6} \]