To calculate \( 6.25 \times 10^6 - 4.73 \times 10^6 \), we start by noting that both terms are in scientific notation with the same exponent \( 10^6 \). We can factor out \( 10^6 \):
\[ 6.25 \times 10^6 - 4.73 \times 10^6 = (6.25 - 4.73) \times 10^6 \]
Next, we perform the subtraction inside the parentheses:
\[ 6.25 - 4.73 = 1.52 \]
Now, we can express the result in scientific notation:
\[ 1.52 \times 10^6 \]
Since \( 1.52 \) is already in the correct format for scientific notation, we just need to ensure it's expressed to two decimal places.
Thus, the final answer is:
\[ \boxed{1.52 \times 10^6} \]