Let \( x \) be the total number of crackers in the box. According to the problem, Ava ate 5 wheat crackers, which is 5% of the entire box. We can express this mathematically as:
\[ 0.05x = 5 \]
To find \( x \), we can solve for \( x \) by dividing both sides of the equation by 0.05:
\[ x = \frac{5}{0.05} \]
Calculating the right side:
\[ x = 100 \]
Therefore, the total number of crackers in the box is \( \boxed{100} \).