In a triangle, the sum of the interior angles is always 180 degrees. From the information provided, we know that angle C is 99 degrees and one of the angles in the line is 22 degrees.
Let's denote the measure of angle A as \( A \).
According to the triangle angle sum property, we have:
\[ A + 22^\circ + C = 180^\circ \]
Substituting the known value of angle C (which is 99 degrees):
\[ A + 22^\circ + 99^\circ = 180^\circ \]
Now, combine the known angles:
\[ A + 121^\circ = 180^\circ \]
Next, to find angle A, we subtract 121 degrees from both sides:
\[ A = 180^\circ - 121^\circ \] \[ A = 59^\circ \]
Thus, the measure of angle A is \( 59^\circ \).
So, the answer is \( \boxed{59^\circ} \).