True, in general. While some individual animals may exhibit less aggressive behavior or develop a degree of comfort around humans, species like leopards, wolves, tigers, bears, and skunks have not been domesticated to the level of living harmoniously with people in a typical household setting. Domestication involves generations of selective breeding for specific traits, such as temperament and sociability, which these wild animals have not undergone.
However, there are exceptions where some animals can be raised in captivity and become accustomed to human interaction, but they often retain their wild instincts and can be unpredictable. Thus, while it may be possible to train individual animals to some extent, it is generally untrue that these species can be fully tamed to live safely and comfortably alongside humans.