Animal testing plays a crucial role in Alzheimer’s research by enabling scientists to explore the underlying mechanisms of the disease and identify potential treatments. Genetically modified mice have been particularly valuable in elucidating the connections between mutations in the amyloid precursor protein and early-onset Alzheimer's disease. By studying these models, researchers can better understand the pathophysiology of the disease and advance the development of targeted therapies.
Moreover, non-human primates contribute significantly to the research landscape by offering insights into the age-related changes in protein expression and function that are associated with cognitive decline. Their closer genetic and physiological similarities to humans enhance the translational potential of the findings, providing a clearer picture of how Alzheimer's disease manifests in the aging brain (Bjørkli et al., 2022).
In summary, through these animal models, researchers are able to dissect the complex biological pathways involved in Alzheimer’s, paving the way for innovative treatment strategies that may one day lead to effective interventions for patients.