To determine which body of water is closest to the Mediterranean Sea, we need to consider the geographic locations of the options provided:
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Niger River - This river flows through West Africa and does not connect directly to the Mediterranean Sea. Its closest point to the Mediterranean is at its mouth where it meets the Atlantic Ocean via the Gulf of Guinea.
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Nile River - The Nile River flows northward through northeastern Africa and empties into the Mediterranean Sea at Alexandria, Egypt. It directly connects to the Mediterranean.
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Lake Chad - This lake is located in Central Africa and is relatively far from the Mediterranean Sea.
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Lake Victoria - Lake Victoria is the largest lake in Africa and is located in East Africa, also quite distant from the Mediterranean Sea.
Based on this geographic analysis, the Nile River is the body of water closest to the Mediterranean Sea, as it flows directly into it.
Response: Nile River