The most accurate response is: The Spanish were searching for wealth and Indigenous people to enslave, but their earliest colony was abandoned.
Early Spanish attempts at colonization in South Carolina were largely driven by the search for wealth, primarily through resources and potential trade, and they often involved the subjugation and enslavement of Indigenous peoples. However, many of these early settlements faced significant challenges, including conflict with local tribes and other European powers, which ultimately led to the abandonment of their initial colonies in the region.