The American settlements that enjoyed profitable farming were:
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Southern plantations - The Southern colonies had large plantations that grew cash crops like tobacco, rice, and indigo.
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The Middle Colonies - The Middle Colonies were known for their fertile soil and were often referred to as the "breadbasket" of the colonies due to the production of grains.
The other two options, "New England" and "the French along the St. Lawrence River," generally did not focus on large-scale profitable farming compared to the Southern colonies and the Middle colonies. New England had a more mixed economy with smaller farms, and the French settlements while they did engage in some farming, were more oriented towards fur trading and relied on different forms of agriculture.
So, the correct answers are Southern plantations and the Middle Colonies.