To find out how many blueberries Amelie and her friends picked, you can multiply the total pounds of blueberries by the number of blueberries in each pound.
Given that Amelie and her friends picked 27 pounds of blueberries and each pound contains 195 blueberries, the calculation is as follows:
\[ 27 \text{ pounds} \times 195 \text{ blueberries/pound} = 5265 \text{ blueberries} \]
Therefore, Amelie and her friends picked 5265 blueberries.