In the sentence you provided, the author makes a contrastive connection between two groups: "younger students" and "the old guard."
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Contrast: The younger students are portrayed as enthusiastic and open to new practices, indicating a willingness to embrace change and innovation. In contrast, the old guard is depicted as resistant to change, having "staked their reputations" on a traditional belief in miasmas. This juxtaposition highlights the generational differences in attitudes toward new ideas.
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Conflict: The differing beliefs between the two groups create a tension or conflict: the progressive views of the younger students are at odds with the traditional views of the older generation.
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Ideological Separation: The mention of "miasmas" represents an outdated scientific belief, suggesting the idea of stagnation in the old guard. In contrast, the enthusiasm of the younger generation symbolizes progress and a move toward new understandings, possibly referencing advancements in fields like medicine or science.
Overall, the author connects contrasting ideas of tradition versus innovation, suggesting a broader theme of the evolution of thought in society.