The correct answer is C: The difference between high and low tide is greatest during full moons and new moons.
This is because during the full moon and new moon phases, the sun, moon, and Earth are aligned, leading to higher high tides and lower low tides, a phenomenon known as "spring tides." Conversely, during the first quarter and last quarter phases, the sun and moon are at right angles relative to the Earth, resulting in lower high tides and higher low tides, known as "neap tides," which leads to a smaller tidal difference.