To calculate the total change in the amount of water in the tank after 6 days, we first determine the amount of water the tank loses each day.
The tank decreases by 10 gallons every 3 hours. There are 24 hours in a day, so we can find out how many 3-hour periods there are in a day:
\[ \text{Number of 3-hour periods in a day} = \frac{24 \text{ hours}}{3 \text{ hours}} = 8 \]
Each of these 3-hour periods contributes to a decrease of 10 gallons. Therefore, the total decrease in gallons per day is:
\[ \text{Daily decrease} = 10 \text{ gallons/period} \times 8 \text{ periods} = 80 \text{ gallons} \]
Now, to find the total decrease over 6 days, we multiply the daily decrease by the number of days:
\[ \text{Total decrease over 6 days} = 80 \text{ gallons/day} \times 6 \text{ days} = 480 \text{ gallons} \]
Thus, the total change in the amount of water in the tank after 6 days is:
\[ \boxed{480} \text{ gallons} \]