The best question to ask in the design of the experiment to determine how to separate the components is:
B: Is the solid large enough to be caught by the pores of a filter?
This question addresses the fundamental separation technique that could be used: filtration. If the solid particles are large enough, they can be effectively separated from the liquid by passing the mixture through a filter. The other options pertain to other methods of separation that may not be applicable or necessary given the nature of the mixture described.