To convert 80 kilometers per hour to miles per hour, you can use the conversion factor that there are approximately 1.6 kilometers in a mile.
\[ \text{Speed in mph} = \frac{\text{Speed in km/h}}{1.6} \]
So,
\[ \text{Speed in mph} = \frac{80 \text{ km/h}}{1.6} \approx 50 \text{ mph} \]
Therefore, the correct response is:
50 miles per hour.