To offset your risk, the best approach among the options provided would be by asking for a higher interest rate.
This option allows you to compensate for the potential higher risk of investing in a business with no prior experience. A higher interest rate would provide you with greater returns that can help offset any potential losses if the business does not succeed.
Other options like opening a savings account or a certificate of deposit would involve a lower return on investment and wouldn't support your friend's business venture. Lending the money without any further arrangements (like a higher interest rate) is risky, especially given your friend's lack of experience.
Overall, seeking a higher interest rate provides a way to manage your investment risk while still supporting your friend's business.