A drug that inhibits the kinase activity of AKT would MOST likely have which of the following effects? Increased GSK-3b activity and increased CyclinD synthesis, increased GSK-3b activity and decreased CyclinD synthesis, Decreased GSK-3b activity and increased CyclinD synthesis, or Decreased GSK-3b activity and decreased CyclinD synthesis.

Answer 1

A drug that inhibits the kinase activity of AKT would most likely have the effect of increased GSK-3b activity and decreased CyclinD synthesis.

AKT is a kinase that activates multiple downstream signaling pathways, including the inhibition of GSK-3b through phosphorylation. GSK-3b is a kinase that regulates various cellular processes, and its inhibition by AKT leads to decreased GSK-3b activity. This results in increased CyclinD synthesis, as GSK-3b normally suppresses CyclinD expression.

By inhibiting the kinase activity of AKT, the drug would prevent the inhibition of GSK-3b, thereby increasing GSK-3b activity. This would subsequently lead to a decrease in CyclinD synthesis, as GSK-3b would no longer be suppressed and would be able to exert its inhibitory effect on CyclinD expression.