A DNA segment has base order CCC ATA GCT. Which copy exhibits a deletion in the first codon triplet and then a substitution mutation?

Responses

CCA TAA CT
CCA TAA CT

CCA TAG CT
CCA TAG CT

CCC TAG CT
CCC TAG CT

CCA ATA GCT

1 answer

To analyze the given DNA segment "CCC ATA GCT", we need to identify the changes caused by a deletion in the first codon triplet (which is "CCC") and then a substitution mutation.

  1. Original Segment: CCC ATA GCT

    • Codon Triplets:
      • 1st codon: CCC
      • 2nd codon: ATA
      • 3rd codon: GCT
  2. Deletion in the First Codon: If we delete one base from the first codon "CCC", it could result in "CC" or "C" if we're removing one ('C'). For mutations, let’s assume the deletion reduces it to "CC".

  3. Substitution Mutation: We can now substitute one base for another in the modified sequence. A common substitution could be replacing a base in the sequence. Let’s proceed with the deletion followed by a substitution.

Starting from the deletion:

  • Deleting one 'C' from "CCC" gives us "CC A ATA GCT" (here I’m assuming one 'C' is removed).

Now let's look at the possible mutations, substituting one base after this deletion:

  • If you substitute the first 'C' in "CC" with 'A', you can create "AC ATA GCT" - but let's check which responses have a logically sound path based on your input options.

The provided options do not reflect precisely one deletion and then a substitution; however, if we analyze the options:

  1. CCA TAA CT: Doesn't match.
  2. CCA TAG CT: Could potentially fit as a substitution after deletion, using the first "CC" as a base point.
  3. CCC TAG CT: This doesn't reflect a deletion, as it remains the same.
  4. CCA ATA GCT: This one shows an addition rather than a straightforward deletion-substitution.

Thus, if we're focusing on which of the given options can come from a deletion followed by a substitution, "CCA TAG CT" best represents a logical progression through a deletion (removing one base from CCC to form CC) and then a substitution in one of the resulting codons.

Final Answer: CCA TAG CT.