To determine which copy exhibits a deletion in the first codon triplet (CCC) and then a substitution mutation, let's analyze each option.
The original base order is: CCC ATA GCT.
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Option A: CCA TAG CT
- First codon has a deletion (C [removed] → CA), so there is a deletion here.
- The second codon has a change from ATA to TAG (substitution mutation).
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Option B: CCC TAG CT
- No deletion in the first codon; it remains CCC. Additionally, no substitution has occurred in the subsequent codons.
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Option C: CCA TAA CT
- The first codon has a deletion (C [removed] → CA). However, this doesn't show a substitution in the second codon because it stays the same as TAA (a point mutation).
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Option D: CCA ATA GCT
- There is a deletion in the first codon (C [removed] → CA) but no substitution in the second codon (ATA).
After analyzing these options, Option A (CCA TAG CT) is the correct one, as it reflects a deletion in the first codon (CCC to CCA) and a substitution mutation (ATA to TAG).