Question

The malate dehydrogenase reaction, written in the direction as it occurs in the citric acid cycle is:

malate + NAD+ → oxaloacetate + NADH + H+ ΔG˚' = +7.1 kcal/mol


Calculate the Keq and ΔG (in kcal/mol) for this reaction at the physiologic mitochondrial concentrations listed below, at 25˚C:

[malate] = 2 x 10-4 M
[NAD+] = 1 x 10-5 M
[OAA] = 1 x 10-8 M
[NADH] = 1 x 10-6 M

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