Asked by Thano
David Hassenzahl discusses the relative risks of eating peanut butter contaminated with aflatoxin and apple juice contaminated with UDMH, a degradation product of Alar, in the Power Point presentation in the Week Five, Module 5 Conference. The following Table shows his input data.
Variable Units Average 5th %ile 95th %ile Distribution
Peanut butter intake g/day 11.38 2.00 31.86 Lognormal
Apple juice intake g/day 136.84 16.02 430.02 Lognormal
Aflatoxin concentration ug/kg 2.82 1.00 6.5 Lognormal
UDMH concentration ug/kg 13.75 0.5 42.00 Lognormal
Aflatoxin potency kg-day/mg 17.5 4.02 28.33 Normal
UDMH potency kg-day/mg 0.49 0.00 0.85 Normal
a. Calculate the daily cancer risk for a child who weighs 20 kg and who eats an average amount of peanut butter
b. Do the same for a 20 kg child who drinks an average amount of apple juice.
NOTE: Daily cancer risk = Intake x Concentration x Potency / Body Weight
c. Calculate the maximum daily cancer risks for peanut butter and apple juice based on the 95th percentiles.
Variable Units Average 5th %ile 95th %ile Distribution
Peanut butter intake g/day 11.38 2.00 31.86 Lognormal
Apple juice intake g/day 136.84 16.02 430.02 Lognormal
Aflatoxin concentration ug/kg 2.82 1.00 6.5 Lognormal
UDMH concentration ug/kg 13.75 0.5 42.00 Lognormal
Aflatoxin potency kg-day/mg 17.5 4.02 28.33 Normal
UDMH potency kg-day/mg 0.49 0.00 0.85 Normal
a. Calculate the daily cancer risk for a child who weighs 20 kg and who eats an average amount of peanut butter
b. Do the same for a 20 kg child who drinks an average amount of apple juice.
NOTE: Daily cancer risk = Intake x Concentration x Potency / Body Weight
c. Calculate the maximum daily cancer risks for peanut butter and apple juice based on the 95th percentiles.
Answers
Answered by
drwls
The Table does not appear in your post.
Answered by
Thano
Variable Units Average 5th %ile 95th %ile Distribution
Peanut butter intake g/day 11.38 2.00 31.86 Lognormal
Apple juice intake g/day 136.84 16.02 430.02 Lognormal
Aflatoxin concentration ug/kg 2.82 1.00 6.5 Lognormal
UDMH concentration ug/kg 13.75 0.5 42.00 Lognormal
Aflatoxin potency kg-day/mg 17.5 4.02 28.33 Normal
UDMH potency kg-day/mg 0.49 0.00 0.85 Normal
Peanut butter intake g/day 11.38 2.00 31.86 Lognormal
Apple juice intake g/day 136.84 16.02 430.02 Lognormal
Aflatoxin concentration ug/kg 2.82 1.00 6.5 Lognormal
UDMH concentration ug/kg 13.75 0.5 42.00 Lognormal
Aflatoxin potency kg-day/mg 17.5 4.02 28.33 Normal
UDMH potency kg-day/mg 0.49 0.00 0.85 Normal
Answered by
Thano
What are the advantages and disadvantages of animal studies and epidemiological studies for establishing dose-response relationships?
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